Age adjusted D-dimer cut-off values (age×10 µg/L) improve specificity without losing sensitivity for venous thromboembolism. This could spare many elderly patients unnecessary imaging.
Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis
BMJ. 2013 May 3;346:f2492
http://www.ncbi.nlm.nih.gov/pubmed/23645857
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